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COVID-2019 has been declared a Public Health Emergency of International Concern (PHEIC) by the World Health Organization due to the global spread of 2019-nCOV at an exponential rate (WHO). Scientists have hypothesized the reduction in transmission rate at warm and humid environment whereas facilitate rapid transmission at cold and dry environment. Hence in this work, we examine the combined impact of environmental and demographic factors along with the implementation of lockdown by the Government of India on the transmission rate of 2019-nCoV. Our analyses indicated a lower mortality rate in spite of higher population density in India compared to other countries and lower exponential growth factor after lockdown compared to before lockdown. The containment of transmission and mortality rate may be attributed to the favorable environment and median population age, respectively. Even though, to significantly reduce the outbreak, individuals, the media, and healthcare organizations are necessary to work together. © 2023 Author(s).
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Chronic overweight is characterized by significant elevations in abdominal fat as well as changes in the composition of fat free mass, particularly total body fluids and its interstitial compartment. The applied in the real restrictions placed by morbid obesity, as well as changes in body content from those of healthy weight, provide enormous hurdles to fat percentage assessment. This research concentrates on some of the research and practice challenges connected with using popular fat percentage measures, and it finds available evidence on suitable approaches for use in extremely obese people. There is already little scientific literature on which body composition measures may be utilised confidently in very obese people. A typical 3 model that combines readings of body mass by air - assisted plethysmography and total body liquid by bio-electrical impedance could provide metrics of percentage body fat in the extremely obese that are significant compared to a conventional, technically skilled 3 storage area prototype that requires infrastructure including such isotopic ratios mass spectrometry as well as important technological knowledge. This study focuses on a few fundamental issues that investigators and physicians confront when doing anthropometric studies on highly obese individuals. A 3 basic framework that is efficient and simple to implement shows potential for usage in this community. Nonetheless, more study on this and other suitable techniques of fat percentage measurement in a broad sample of extremely overweight adults is required. © 2023 Author(s).
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A global outbreak of coronavirus disease 2019 (COVID-19), an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), mounted a substantial threat to public health worldwide. It initially emerged as a mere outbreak in Wuhan, China, in December 2019 and quickly engulfed the entire world, evolving into a global pandemic, consuming millions of lives and leaving a catastrophic effect on our lives in ways unimaginable. The entire healthcare system was significantly impacted and HIV healthcare was not spared. In this article, we reviewed the effect of HIV on COVID-19 disease and the ramifications of the recent COVID-19 pandemic over HIV management strategies. Our review highlights that contrary to the instinctive belief that HIV should render patients susceptible to COVID-19 infection, the studies depicted mixed results, although comorbidities and other confounders greatly affected the results. Few studies showed a higher rate of in-hospital mortality due to COVID-19 among HIV patients; however, the use of antiretroviral therapy had no consequential effect. COVID-19 vaccination was deemed safe among HIV patients in general. The recent pandemic can destabilize the HIV epidemic control as it hugely impacted access to care and preventive services and led to a marked reduction in HIV testing. The collision of these two disastrous pandemics warrants the need to materialize rigorous epidemiological measures and health policies, but most importantly, brisk research in prevention strategies to mitigate the combined burden of the two viruses and to battle similar future pandemics.
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The coronavirus pandemic had a tremendous impact on the hotel industry worldwide. The present study highlights strategic directions for quality improvements and customer satisfaction enhancement in Wuhan hotels by applying Multiple Criteria Satisfaction Analysis to online user-generated satisfaction ratings. In total, 21.247 guest satisfaction ratings on four aspects of hotel stay (location, cleanliness, value for money and service) as well as on overall satisfaction for the 406 hotels listed for Wuhan on TripAdvisor were retrieved. The analysis revealed that convenient location is the most important satisfaction criterion for hotel guests' satisfaction and that hotels perform well regarding this criterion. Also, cleanliness, value for moneyand service can be potential threats for customer satisfaction. [ FROM AUTHOR] Copyright of Anatolia: An International Journal of Tourism & Hospitality Research is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
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OBJECTIVE: To describe the factors associated with the requirement of invasive mechanical ventilation (IMV) and mortality in COVID-19 patients diagnosed in a tertiary-care center in Mexico City. MATERIALS AND METHODS: A cross-sectional study was done including consecutive patients with COVID-19 from March 18 to July 30, 2020. RESULT(S): Nine hundred forty-six patients were analyzed. The median age was 53 years (interquartile range, 44-53), 64% men, and 22.2% received invasive mechanical ventilation. The overall mortality was 23.3%, and 50% in the intensive care unit. In the logistic regression analysis, a severe tomographic pattern (STP) (odds ratio [OR] 23.8, 95% confidence interval [95% CI] 6.9-81.3), troponin I > 20 pg/mL (OR 7.1, 95% CI 3.9-12.9) and hyperglycemia (> 180 mg/dL) at admission (OR 2.8, 95% CI 1.6-4.8) were associated with requirement of IMV (p < 0.001). A severe tomographic pattern (OR 18.6, 95% CI 2.5-138.7), troponin I > 20 pg/mL (OR 4.9, 95% CI 3.2-7.4), age between 44-64 years (OR 2.7, 95% CI 1.7-4.1), age >= 65 years (OR 2.9, 95% CI 1.7-5.0), hyperglycemia (OR 1.9, 95% CI 1.2-3.2) and male sex (OR 1.6, 95% CI 1.1-2.4) increased mortality (p < 0.001). CONCLUSION(S): A severe tomographic pattern, high troponin I, and hyperglycemia at admission were associated with invasive mechanical ventilation requirement and increased mortality due to COVID-19.Copyright © 2022 Comunicaciones Cientificas Mexicanas S.A. de C.V.. All rights reserved.
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Transportation management plays a vital role in the development of the country, with the help of IoT smart transportation has become a reality. Developing a smart and secured transportation system of food products to various shops during this pandemic period is an important task. The vehicle tracking system is the technology that is used by many companies and individuals to track a vehicle by using many ways like GPS that operates using satellites and ground-based stations. In this paper an Internet of Things based application is developed to monitor the moving vehicle, this proposed model provides a monitoring solution for a moving vehicle with the help of sensors Blind Spot Assist sensor, Collision Prevention sensor, Fuel Monitoring sensor, Door Sensor, and GPS/GPRS tracking module are integrated to make a smart vehicle prototype using raspberry pi. In this model, a Blind spot sensor is used to monitor the nearby vehicles, a Collision Prevision sensor is used to avoid the collision between the vehicles, a Fuel monitoring sensor is used to monitor the fuel level in the vehicle, the Door sensor is used to check the status of the door and GPS/GPRS tracking module is used to track the current location of the moving vehicle during the COVID-19 Pandemic period.
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BACKGROUND: Myocardial injury in patients with COVID-19 and suspected cardiac involvement is not well understood. OBJECTIVES: The purpose of this study was to characterize myocardial injury in a multicenter cohort of patients with COVID-19 and suspected cardiac involvement referred for cardiac magnetic resonance (CMR). METHODS: This retrospective study consisted of 1,047 patients from 18 international sites with polymerase chain reaction-confirmed COVID-19 infection who underwent CMR. Myocardial injury was characterized as acute myocarditis, nonacute/nonischemic, acute ischemic, and nonacute/ischemic patterns on CMR. RESULTS: In this cohort, 20.9% of patients had nonischemic injury patterns (acute myocarditis: 7.9%; nonacute/nonischemic: 13.0%), and 6.7% of patients had ischemic injury patterns (acute ischemic: 1.9%; nonacute/ischemic: 4.8%). In a univariate analysis, variables associated with acute myocarditis patterns included chest discomfort (OR: 2.00; 95% CI: 1.17-3.40, P = 0.01), abnormal electrocardiogram (ECG) (OR: 1.90; 95% CI: 1.12-3.23; P = 0.02), natriuretic peptide elevation (OR: 2.99; 95% CI: 1.60-5.58; P = 0.0006), and troponin elevation (OR: 4.21; 95% CI: 2.41-7.36; P < 0.0001). Variables associated with acute ischemic patterns included chest discomfort (OR: 3.14; 95% CI: 1.04-9.49; P = 0.04), abnormal ECG (OR: 4.06; 95% CI: 1.10-14.92; P = 0.04), known coronary disease (OR: 33.30; 95% CI: 4.04-274.53; P = 0.001), hospitalization (OR: 4.98; 95% CI: 1.55-16.05; P = 0.007), natriuretic peptide elevation (OR: 4.19; 95% CI: 1.30-13.51; P = 0.02), and troponin elevation (OR: 25.27; 95% CI: 5.55-115.03; P < 0.0001). In a multivariate analysis, troponin elevation was strongly associated with acute myocarditis patterns (OR: 4.98; 95% CI: 1.76-14.05; P = 0.003). CONCLUSIONS: In this multicenter study of patients with COVID-19 with clinical suspicion for cardiac involvement referred for CMR, nonischemic and ischemic patterns were frequent when cardiac symptoms, ECG abnormalities, and cardiac biomarker elevations were present.
Subject(s)
COVID-19 , Coronary Artery Disease , Heart Injuries , Myocarditis , Humans , Myocarditis/pathology , COVID-19/complications , Retrospective Studies , Predictive Value of Tests , Magnetic Resonance Imaging , Troponin , Magnetic Resonance SpectroscopyABSTRACT
BACKGROUND: To counteract the coronavirus disease 2019 (COVID-19) pandemic, several severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) vaccines have been licensed since December 2020. Shortly after the start of the vaccination campaigns, occasional allergic reactions related to vaccines were described, thus, leading to concerns in many patients with a history of allergies. The aim of this work was to evaluate which anamnestic events represented a reason for an allergology work-up before COVID-19 vaccination. Furthermore, the results of the allergology diagnostics are described. METHODS: We performed a retrospective data analysis of all patients who presented at the Center for Dermatology, Allergology and Dermatosurgery of the Helios University Hospital Wuppertal during the years 2021 and 2022 for allergology work-up prior to COVID-19 vaccination. Demographic data, allergological history, reason for the consultation in the clinic and results of allergology diagnostic tests including reactions after vaccination were included. RESULTS: A total of 93 patients presented for allergology work-up with COVID-19 vaccines. In about half of the cases, the reasons for the presentation to the clinic were doubts and concerns about allergic reactions and side effects. In all, 26.9% (25/93) of the presented patients had not previously received a COVID-19 vaccine yet and 23.7% (22/93) of patients developed non-allergic reactions after prior COVID-19 vaccine (e.g., headache, chills, fever, malaise). Of the patients, 46.2% (43/93) were successfully vaccinated in the clinic due to a complex allergological history, while the remaining 53.8% (50/93) were subjected to outpatient vaccination in the vaccination practice. Only one patient with known chronic spontaneous urticaria developed a mild angioedema of the lips a few hours after vaccination; however, we do not consider this episode an allergic reaction to the vaccine due to the time delay. CONCLUSION: Allergic reactions after COVID-19 vaccines are rare, but many patients with a positive medical history of allergies are concerned about allergic reactions after COVID-19 vaccination. Thus, public work by practicing allergologists is important during vaccination campaigns to meet the concerns and fears of the population, especially of patients with allergies in their medical history.
Subject(s)
Angioedema , COVID-19 Vaccines , COVID-19 , Humans , COVID-19/epidemiology , COVID-19/prevention & control , COVID-19 Vaccines/adverse effects , Retrospective Studies , SARS-CoV-2 , Vaccination/adverse effectsABSTRACT
BACKGROUND: COVID-19 has been linked to a variety of dermatological conditions. OBJECTIVE: To determine the presence of various cutaneous manifestations in patients with COVID-19, also to define their features in relation to the systemic symptoms. METHODS: This research enrolled a total of 1206 lab-confirmed COVID-19 individuals at a tertiary-care hospital in Karachi, Pakistan. Expert dermatologists assessed patients for COVID-related skin conditions. COVID-19 severity was categorized as asymptomatic/mild, moderate, or severe. RESULTS: Of the 102 (85.7%) patients with only one cutaneous sign, 26.5% developed maculopapular/morbiliform/erythematous rash; 14.7% urticaria; 9.85% vesicular/pustular exanthem; 14.7% vascular pattern; 12.7% infections, 7.8% miscellaneous and 9.8% late cutaneous findings A longer-lasting vascular pattern was related with an older age and a fatal COVID-19 outcomes (P: 0.000) compared with mild/moderate disease. Most of the retiform purpura presented exclusively with thromboembolic episodes. The moderate severity was correlated with maculopapular/morbiliform/exanthematous phenotype (P: 0.009), whereas urticaria was attributed to asymptomatic/mild disease (0.001) compared with moderate/severe infection. LIMITATIONS: Single-Center and observational study. CONCLUSION: Vascular lesions were correlated with disastrous COVID-19 outcomes, whereas retiform purpura was linked to adverse outcomes. The maculopapular/morbiliform/erythematous rash was associated with moderate severity, while the urticarial rash was linked to milder course compared with moderate/severe severity infection.
Subject(s)
COVID-19 , Drug Eruptions , Exanthema , Purpura , Urticaria , COVID-19/complications , Exanthema/diagnosis , Exanthema/etiology , Humans , SARS-CoV-2 , Urticaria/etiologyABSTRACT
Covid-19 is caused by a newly detected coronavirus (SARS-CoV-2). It is a respiratory infection that usually spreads from individual to individual through sneezing or coughing. The disease, which was first detected in the province of Wuhan, China, had effected more than one continent and was declared as a pandemic by the World Health Organization (WHO). The pandemic has affected health, social, economic, and psychological segments of life for billions of people. Though vaccines have been developed and are made available, we are still prone to the virus, which is similar to any other flu. This chapter presents an analysis of the symptoms of the disease and identifies significant symptoms that impact the cause of the illness. Machine learning techniques like multiple regression, support vector machine (SVM), Decision Tree, Random Forest, and Logistic Regression are applied to understand the evaluation with respect to the measures like coefficient of determination, and mean-squared error. Hypothesis testing is used to determine whether at least one of the features is useful in the diagnosis of the disease. Further feature selection process is used to identify the most significant symptoms that will cause the virus. Different visualization methods are used to figure the substantial reasoning from the model's prediction and perform analysis on the results obtained. © 2023 Elsevier Inc. All rights reserved.
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The COVID-2019 pandemic has a huge impact on tourism industry, and mastering the spatial and temporal characteristics of tourists' travel behavior during the period is very crucial for the recovery and the development of the tourism industry. This study adopts time series statistics and complex network analysis to compare and examine the network evolution features of Hong Kong before and during the COVID-19 pandemic based on the comments data generated from TripAdvisor website in 2019 and 2020. The results show that: (1) Tourists' travel behavior patterns have changed to a certain degree, and they prefer to visit a small number of destinations during an itinerary. (2) Key destinations still play important roles in connecting other destinations, but the tourism community formed around the key destinations has varied from extremely dense to relatively sparse gathering. (3) The number of tourists in extremely hot destinations has been greatly declined, those destinations with fewer tourists and relatively far away from the downtown have attracted more attention. Moreover, industrial destinations have been always the most popular type of tourism destination. © 2022, Science Press. All rights reserved.
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Mass vaccination against coronavirus disease 2019 (COVID-19) has been safe and effective. The ongoing emergence of vaccine-induced complications has challenged the public trust in vaccination programs and, though uncommon, can lead to significant morbidity and mortality. Vaccine-induced immune thrombocytopenia and thrombosis (VITT) is a rare and fatal complication of the COVID-19 vaccine. We present a rare case of VITT in a young female who presented with worsening headache, body rash with deteriorating neurological deficit after 12 days of the second dose of the ChAdOx1 COVID-19 vaccine. Initial blood tests showed thrombocytopenia with deranged clotting time and D-dimer levels. Her computed tomography venogram showed thrombosis in the left transverse sinus, and she was diagnosed with a provisional diagnosis of VITT. She initially managed with dexamethasone, intravenous immunoglobulins, and apixaban to reverse the autoimmune process. Our case highlights the clinical course, diagnosis, and management of VITT, which will assist physicians in the timely recognition and adequate management of VITT.
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The outbreak situation of the COVID-2019 pandemic is an Unpredictable shock to the world economy. World Economy faces the slowdown of share market prices, especially the value of mutual fund value decreases. Companies and Businessmen primarily invested in the mutual funds to play a safer role, modify their risk into the return, and increase the Net Assets Value (NAV). This study attempts to describe the state of mutual funds in India during this COVID 2019 period. Thus the performance of mutual funds when compared with before and during COVID 2019, the proposed model specifies on testing the performance of mutual funds both in the public and private sectors and attains to access the impact of COVID 2019 on mutual funds. The author has used correlation for finding out the relation of COVID 2019 and Mutual Funds. This paper mainly addresses the causes of investors during economic fluctuation and the return of top mutual companies by comparing the return of 1 year and during these last three months. COVID 2019 is not only on particular sectors;it affects almost every sector like construction, manufacturing, business, agriculture. While all the sectors are affected by COVID 2019 pandemics, it hits the society and the economy;once the economy comes down, the inflation rate increase, the Forex rate will increase, and it affects our whole country. In this paper, the author included sectors that are affected and their performance now and how well the different types of funds are performing, which will be helpful for the reader to analyze the affected areas. The paper concluded with the help of a survey and statistical tools whether the investors can make a further payment and hold for some period or continue with the investment whatever situation crisis impacts our economy. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.
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[Display omitted] • Porous hollow carbon spheres (HCSs) with adjustable size and pore width distribution were synthesized. • The clearance rate of HCSs to interleukin 6 (IL-6) in PBS buffer solution was up to 99.8%. • HCSs had a high adsorption rate and removal efficiency for PTH, β 2 -MG, IL-6 and TNF-α in the serum of uremic patients. • The selective adsorption of middle-macromolecular toxins or cytokines was achieved by regulating the pore structure of HCSs. Abnormally elevated middle-macromolecular toxins such as interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF- α) in human blood are fatal precipitating factors for patients suffered from immune-related diseases, especially for uremia and COVID-19 critical patients, while the effective clearance of them has always been problematic in clinic. In this work, porous hollow carbon spheres (HCSs) with different size and pore structure has been successfully prepared. The removal efficiency for IL-6 in PBS solution is about 99.8 %, even in the serum of uremic patients, HCSs could remove 94.75 % and 98.33 % of parathyroid hormone (PTH) and β 2 -microglobulin (β 2 -MG) efficiently within 5–10 min, and particularly, the adsorption of IL-6 and TNF- α is 17.6 and 11.4 times higher over that of the existing commercial hemoperfusion adsorbents. The adsorption balance can be achieved in 60 min, which would greatly shorten the current clinical treatment duration. Moreover, HCSs with different pore structure exhibit distinct adsorption selectivity for IL-6 and TNF- α, which is of special significance for modifying the middle-macromolecular cytokine level in the complicated human blood environment. [ FROM AUTHOR]
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The impact of the COVID-2019 pandemic varies significantly across different groups of countries, depending on their level of socioeconomic development and the type of national anti-COVID policies. The author considers the features of the social consequences of the covid-crisis in catch-up countries using the case of China, where in 2020–2022 an artificial isolation was effected as a part zero tolerance policy. The study is based on a sociological survey conducted by the author (N = 4842) using a random sampling in two cities of the Northeastern provinces of the PRC, bordering the Primorsky Territory of the Russian Federation, and significantly dependent on economic ties with Russia sharply decreased during the pandemic. Many specific changes in employment of the population were revealed: a general decline in the standard of living (almost 2/3 of the respondents), mass layoffs (more than a quarter), increase in gender inequality. It was found that the impact of the pandemic on employment and quality of life is especially negative for China's informally employed population. © 2022, Russian Academy of Sciences. All rights reserved.
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The impact of the COVID-2019 pandemic varies significantly across different groups of countries, depending on their level of socioeconomic development and the type of national anti-COVID policies. The author considers the features of the social consequences of the covid-crisis in catch-up countries using the case of China, where in 2020-2022 an artificial isolation was effected as a part zero tolerance policy. The study is based on a sociological survey conducted by the author (N = 4842) using a random sampling in two cities of the Northeastern provinces of the PRC, bordering the Primorsky Territory of the Russian Federation, and significantly dependent on economic ties with Russia sharply decreased during the pandemic. Many specific changes in employment of the population were revealed: a general decline in the standard of living (almost 2/3 of the respondents), mass layoffs (more than a quarter), increase in gender inequality. It was found that the impact of the pandemic on employment and quality of life is especially negative for China's informally employed population.
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Organization of Economic Cooperation and Development (OECD) economies are facing a substantial increase in the information and communication technology (ICT) investments in the context of rapid spread of the Coronavirus Disease-2019 (COVID-2019) pandemic and constraints of emissions reduction. However, the mechanism of the impact of ICT investments on carbon dioxide is still unclear. Therefore, by employing the decoupling-factor model and Generalized Divisia Index Method, we explore the decoupling states of ICT investments and emission intensity, and the driving factors of ICT investments' scale, intensity, structure, and efficiency effects on carbon emissions in 20 OECD economies between 2000 and 2018. The results indicate that the number of economies with an ideal state of strong decoupling rose to nine between 2009 and 2018 compared to no economies between 2000 and 2009. The emission intensity of ICT investments contributes to a significant increase of carbon emissions, and the structure and efficiency of ICT investments always restrain the growth of carbon emissions. Significant emissions changes caused by the driving factors are shown in many economies before and after the crisis, reflecting the differences in the strategic choices of ICT investments and the impact on emissions due to the crisis such as the COVID-2019 pandemic. And policy implications for energy and carbon dioxide mitigation strategies in the post-COVID-2019 era are also provided.
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Several Phase-III clinical studies investigating vaccine safety and effectiveness have been published a year following the first breakout of the COVID-19 pandemic. These vaccine candidates were produced using a variety of vaccination technologies, including mRNA, recombinant protein, adenoviral vector, and inactivated virus-based platforms, by various research organizations and pharmaceutical firms. Despite many successful clinical studies, participants are restricted by trial inclusion and exclusion criteria, geographic location, and the current state of the virus epidemic. Many concerns remain, particularly for specific populations such as the elderly, women who are pregnant or nursing, and teenagers. Vaccine effectiveness against asymptomatic infection and particular viral variations, on the other hand, is still largely unclear. This review will focus on vaccination candidates that have completed Phase-III clinical trials and will examine the scientific evidence that has been gathered so far for these vaccine candidates for various subgroups of individuals and virus variations.
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BACKGROUND: Gastrointestinal (GI) bleeding is one of the most impactful complications in patients hospitalized from COVID-19 infection. Limited study has focused on patients with upper GI bleeding (UGIB). This study aimed to identify the risk factors of patients who were hospitalized from COVID-19 infection and developed UGIB as well as the effectiveness of proton pump inhibitor (PPI) prophylaxis in those patients. METHODS: This study was comprised of two phases. The first phase was the retrospective enrollment of patients who were admitted due to COVID-19 infection and developed UGIB between April and August 2021 to evaluate the associated factors of active UGIB. The second phase was a retrospective analysis after PPI prophylaxis protocol from September - October 2021 to assess the benefit of PPI use in those patients. RESULTS: Of 6,373 patients hospitalized, 43 patients (0.7%) had evidence of UGIB. The majority were male 28 (65.1%) with a mean age of 69.1 ± 11.8 years. Twenty-four of 43 patients (55.8%) needed mechanical ventilation, 35 patients (81.4%) received systemic corticosteroids, and 10 patients (23.3%) were taking anticoagulants for venous thromboembolic prophylaxis. Seven of 43 patients (16%) had active UGIB. There was no significant difference in the number of patients taking antiplatelets, anticoagulants, or steroids and the severity of COVID-19 infection between the two groups. An emergency endoscopy or endoscopic hemostasis were performed in 6/7 (85.7%) patients. The multivariate logistic regression analysis revealed two significant factors associated with active UGIB including higher of Glasgow-Blatchford score (GBS) per point (OR = 7.89; 95%CI 1.03-72.87; p = 0.04) and an absence of PPI use (OR 4.29; 95%CI 1.04-19.51; p = 0.04). After prescribing PPI as a prophylaxis, there was a slightly lower incidence of UGIB (0.6% vs 0.7%) in addition to an absence of active UGIB (0% vs 16%). CONCLUSION: Our study demonstrated that the absence of PPI and higher GBS were significant risk factors for active UGIB which required therapeutic endoscopy in patients with COVID-19 infection. We suggest that short-term PPI prophylaxis should be prescribed in those patients once they need hospitalization regardless of the severity of COVID-19 infection to minimize the severity of UGIB.
Subject(s)
COVID-19 , Proton Pump Inhibitors , Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Proton Pump Inhibitors/therapeutic use , Retrospective Studies , COVID-19/complications , Gastrointestinal Hemorrhage/chemically induced , Gastrointestinal Hemorrhage/prevention & control , Risk Factors , Endoscopy, Gastrointestinal/adverse effects , Anticoagulants/adverse effectsABSTRACT
Aim To determine the antiviral and anti-inflammatory effects of the recommended prescription for COVID-2019-lung-spleen qi deficiency(4-1)against in vitro infection of SARS-CoV-2 and common coronaviruses.Methods The main chemical substances of 4-1 were analyzed by LC-MS.The toxicity and antiviral effects of of 4-1 were detected by MTT and by CPE assay, respectively.The viral loads in cell supernatant and the expression of inflammatory factors induced by viral infection were determined by qRT-PCR.Results The recommended prescription 4-1 contained 94 chemical compounds, including flavonoids, steroids, sesquiterpenoids, and so on.The range of selection indexes for SARS-CoV-2 and common coronaviruses was 8.44+/-0.49~52.26+/-2.3.This prescription could inhibit the proliferation of SARS-CoV-2, the expression of ACE2 and S mRNA, and down regulate IL-1alpha and CCL-5/RANTES at 10, 5, and 2.5 g*L-1 doses.Further, at doses of 20, 10 and 5 g*L-1, it could inhibit the proliferation of three common coronaviruses and suppress the overexpression of IL-6, CXCL-8/IL-8, CXCL-10/IP-10, TNF-alpha, IFN-alpha, CCL-2/MCP-1, MIG and CCL-5/RANTES induced by OC43/229E infection.The inhibitory effects were dose-dependent.Conclusions The prescription 4-1 has antiviral and anti-inflammation effects against multiple coronaviruses.This study provides the research basis for the treatment of common respiratory viral infections and emerging infectious diseases such as COVID-19 by using traditional Chinese medicine. Copyright © 2022 Publication Centre of Anhui Medical University. All rights reserved.